Recording long-term potentiation of synaptic transmission by three-dimensional multi-electrode arrays.

ABSTRACT:

Background

Multi-electrode arrays (MEAs) have become popular tools for recording spontaneous and evoked electrical activity of excitable tissues. The majority of previous studies of synaptic transmission in brain slices employed MEAs with planar electrodes that had limited ability to detect signals coming from deeper, healthier layers of the slice. To overcome this limitation, we used three-dimensional (3D) MEAs with tip-shaped electrodes to probe plasticity of field excitatory synaptic potentials (fEPSPs) in the CA1 area of hippocampal slices of 129S5/SvEvBrd and C57BL/6J-TyrC-Brd mice.

Results

Using 3D MEAs, we were able to record larger fEPSPs compared to signals measured by planar MEAs. Several stimulation protocols were used to induce long-term potentiation (LTP) of syn

SUBMITTER: Kopanitsa MV 

PROVIDER: S-EPMC1574331 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature