Simulation of microarray data with realistic characteristics.

ABSTRACT:

Background

Microarray technologies have become common tools in biological research. As a result, a need for effective computational methods for data analysis has emerged. Numerous different algorithms have been proposed for analyzing the data. However, an objective evaluation of the proposed algorithms is not possible due to the lack of biological ground truth information. To overcome this fundamental problem, the use of simulated microarray data for algorithm validation has been proposed.

Results

We present a microarray simulation model which can be used to validate different kinds of data analysis algorithms. The proposed model is unique in the sense that it includes all the steps that affect the quality of real microarray data. These steps include the simulation of biolog

SUBMITTER: Nykter M 

PROVIDER: S-EPMC1574357 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature