Leishmania isoenzyme polymorphisms in Ecuador: relationships with geographic distribution and clinical presentation.

ABSTRACT:

Background

Determinants of the clinical presentation of the leishmaniases are poorly understood but Leishmania species and strain differences are important. To examine the relationship between clinical presentation, species and isoenzyme polymorphisms, 56 Leishmania isolates from distinct presentations of American tegumentary leishmaniasis (ATL) from Ecuador were analyzed.

Methods

Isolates were characterized by multilocus enzyme electrophoresis for polymorphisms of 11 isoenzymes. Patients were infected in four different ecologic regions: highland and lowland jungle of the Pacific coast, Amazonian lowlands and Andean highlands.

Results

Six Leishmania species constituting 21 zymodemes were identified: L. (Viannia) panamensis (21 isolates, 7 zymodemes), L. (V.) guyanensi

SUBMITTER: Calvopina M 

PROVIDER: S-EPMC1578576 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature