Melanoma cell adhesion molecule is a novel marker for human fetal myogenic cells and affects myoblast fusion.

ABSTRACT: Myoblast fusion is a highly regulated process that is important during muscle development and myofiber repair and is also likely to play a key role in the incorporation of donor cells in myofibers for cell-based therapy. Although several proteins involved in muscle cell fusion in Drosophila are known, less information is available on the regulation of this process in vertebrates, including humans. To identify proteins that are regulated during fusion of human myoblasts, microarray studies were performed on samples obtained from human fetal skeletal muscle of seven individuals. Primary muscle cells were isolated, expanded, induced to fuse in vitro, and gene expression comparisons were performed between myoblasts and early or late myotubes. Among the regulated genes, melanoma cell adhesion m

SUBMITTER: Cerletti M 

PROVIDER: S-EPMC1578761 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature