Trypanin, a component of the flagellar Dynein regulatory complex, is essential in bloodstream form African trypanosomes.

ABSTRACT: The Trypanosoma brucei flagellum is a multifunctional organelle with critical roles in motility, cellular morphogenesis, and cell division. Although motility is thought to be important throughout the trypanosome lifecycle, most studies of flagellum structure and function have been restricted to the procyclic lifecycle stage, and our knowledge of the bloodstream form flagellum is limited. We have previously shown that trypanin functions as part of a flagellar dynein regulatory system that transmits regulatory signals from the central pair apparatus and radial spokes to axonemal dyneins. Here we investigate the requirement for this dynein regulatory system in bloodstream form trypanosomes. We demonstrate that trypanin is localized to the flagellum of bloodstream form trypanosomes, in a patte

SUBMITTER: Ralston KS 

PROVIDER: S-EPMC1579245 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature