Mapping of the juxtacentromeric heterochromatin-euchromatin frontier of human chromosome 21.

ABSTRACT: Euchromatin and heterochromatin are functional compartments of the genome. However, little is known about the structure and the precise location of the heterochromatin-euchromatin boundaries in higher eukaryotes. Constitutive heterochromatin in centromeric regions is associated with (1) specific histone methylation patterns, (2) high levels of DNA methylation, (3) low recombination frequency, and (4) the repression of transcription. All of this contrasts with the permissive structure of euchromatin found along chromosome arms. On the sequence level, the transition between these two domains consists most often of patchworks of segmental duplications. We present here a comprehensive analysis of gene expression, DNA methylation in CpG islands, distribution of histone isoforms, and recombinati

SUBMITTER: Grunau C 

PROVIDER: S-EPMC1581429 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature