Pharmacological prevention of serious anaphylactic reactions due to iodinated contrast media: systematic review.

ABSTRACT:

Objective

To review the efficacy of pharmacological prevention of serious reactions to iodinated contrast media.

Design

Systematic review.

Data sources

Systematic search (multiple databases, bibliographies, all languages, to October 2005) for randomised comparisons of pretreatment with placebo or no treatment (control) in patients receiving iodinated contrast media. Review methods Trial quality was assessed by all investigators. Information on trial design, population, interventions, and outcomes was abstracted by one investigator and cross checked by the others. Data were combined by using Peto odds ratios with 95% confidence intervals.

Results

Nine trials (1975-96, 10 011 adults) tested H1 antihistamines, corticosteroids, and an H1-H2 combination. No trial in

SUBMITTER: Tramer MR 

PROVIDER: S-EPMC1584363 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature