Infertility, infertility treatment, and congenital malformations: Danish national birth cohort.

ABSTRACT:

Objectives

To examine whether infertile couples (with a time to pregnancy of > 12 months), who conceive naturally or after treatment, give birth to children with an increased prevalence of congenital malformations.

Design

Longitudinal study.

Setting

Danish national birth cohort.

Participants

Three groups of liveborn children and their mothers: 50,897 singletons and 1366 twins born of fertile couples (time to pregnancy < or = 12 months), 5764 singletons and 100 twins born of infertile couples who conceived naturally (time to pregnancy > 12 months), and 4588 singletons and 1690 twins born after infertility treatment.

Main outcome measures

Prevalence of congenital malformations determined from hospital discharge diagnoses.

Results

Compared with singl

SUBMITTER: Zhu JL 

PROVIDER: S-EPMC1584372 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature