Generalization of DNA microarray dispersion properties: microarray equivalent of t-distribution.

ABSTRACT:

Background

DNA microarrays are a powerful technology that can provide a wealth of gene expression data for disease studies, drug development, and a wide scope of other investigations. Because of the large volume and inherent variability of DNA microarray data, many new statistical methods have been developed for evaluating the significance of the observed differences in gene expression. However, until now little attention has been given to the characterization of dispersion of DNA microarray data.

Results

Here we examine the expression data obtained from 682 Affymetrix GeneChips with 22 different types and we demonstrate that the Gaussian (normal) frequency distribution is characteristic for the variability of gene expression values. However, typically 5 to 15% of the sample

SUBMITTER: Novak JP 

PROVIDER: S-EPMC1586001 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature