Effect of random and hub gene disruptions on environmental and mutational robustness in Escherichia coli.

ABSTRACT:

Background

Genome-wide profiling has allowed the regulatory interaction networks of many organisms to be visualised and the pattern of connections between genes to be studied. These networks are non-random, following a power-law distribution with a small number of well-connected 'hubs' and many genes with only one or a few connections. Theoretical work predicts that power-law networks display several unique properties. One of the most biologically interesting of these is an intrinsic robustness to disturbance such that removal of a random gene will have little effect on network function. Conversely, targeted removal of a hub gene is expected to have a large effect.

Results

We compared the response of Escherichia coli to environmental and mutational stress following disruptio

SUBMITTER: Cooper TF 

PROVIDER: S-EPMC1590030 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature