Valproate, thalidomide and ethyl alcohol alter the migration of HTR-8/SVneo cells.

ABSTRACT:

Background

Valproate, thalidomide and alcohol (ethanol) exposure during the first trimester of pregnancy is known to cause several developmental disorders. All these teratogens are known to pass the placental barrier and interfere directly with the normal development of the fetus. However, these teratogens also alter the formation and function of the placenta itself which may in turn affect the proper nourishment and development of the fetus. Optimum development of the placenta requires adequate invasion of trophoblast into the maternal uterine tissues. Changes in the migratory behavior of trophoblast by maternal exposure to these teratogens during placentogenesis may therefore alter the structure and function of the placenta.

Methods

In the present study, the effects of sod

SUBMITTER: Rout UK 

PROVIDER: S-EPMC1592099 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature