Glycogen synthase kinase 3 has a limited role in cell cycle regulation of cyclin D1 levels.

ABSTRACT:

Background

The expression level of cyclin D1 plays a vital role in the control of proliferation. This protein is reported to be degraded following phosphorylation by glycogen synthase kinase 3 (GSK3) on Thr-286. We recently showed that phosphorylation of Thr-286 is responsible for a decline in cyclin D1 levels during S phase, an event required for efficient DNA synthesis. These studies were undertaken to test the possibility that phosphorylation by GSK3 is responsible for the S phase specific decline in cyclin D1 levels, and that this event is regulated by the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway which controls GSK3.

Results

We found, however, that neither PI3K, AKT, GSK3, nor proliferative signaling activity in general is responsible for the S phase de

SUBMITTER: Yang K 

PROVIDER: S-EPMC1592484 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature