Genetic analysis of MEFV gene pyrin domain in patients with Behcet's disease.

ABSTRACT:

Objectives

Behçet's disease (BD) is a systemic vasculitis with recurrent oral and genital ulcers and uveitis. MEFV gene, which is the main factor in familial Mediterranean fever (FMF), is also reported to be a susceptibility gene for BD. The pyrin domain of MEFV gene is a member of death-domain superfamily and has been proposed to regulate inflammatory signaling in myeloid cells. This study was designed to determine if mutations in pyrin domain of MEFV gene are involved in BD.

Methods

We analyzed the pyrin domain of MEFV gene in 54 Turkish patients with BD by PCR-analysis and direct sequencing.

Results

Neither deletion or insertion mutations nor point mutations in pyrin domain were found in any patient.

Conclusion

Although pyrin gene mutations have been reporte

SUBMITTER: Dursun A 

PROVIDER: S-EPMC1592598 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature