Loss of FilaminC (FLNc) results in severe defects in myogenesis and myotube structure.

ABSTRACT: FilaminC (FLNc) is the muscle-specific member of a family of actin binding proteins. Although it interacts with many proteins involved in muscular dystrophies, its unique role in muscle is poorly understood. To address this, two models were developed. First, FLNc expression was stably reduced in C2C12 myoblasts by RNA interference. While these cells start differentiation normally, they display defects in differentiation and fusion ability and ultimately form multinucleated "myoballs" rather than maintain elongated morphology. Second, a mouse model carrying a deletion of last 8 exons of Flnc was developed. FLNc-deficient mice die shortly after birth, due to respiratory failure, and have severely reduced birth weights, with fewer muscle fibers and primary myotubes, indicating defects in prim

SUBMITTER: Dalkilic I 

PROVIDER: S-EPMC1592847 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature