Prevalence of newer beta-lactamases in gram-negative clinical isolates collected in the United States from 2001 to 2002.

ABSTRACT: Newer beta-lactamases such as extended-spectrum beta-lactamases (ESBLs), transferable AmpC beta-lactamases, and carbapenemases are associated with laboratory testing problems of false susceptibility that can lead to inappropriate therapy for infected patients. Because there appears to be a lack of awareness of these enzymes, a study was conducted during 2001 to 2002 in which 6,421 consecutive, nonduplicate clinical isolates of aerobically growing gram-negative bacilli from patients at 42 intensive care unit (ICU) and 21 non-ICU sites across the United States were tested on-site for antibiotic susceptibility. From these isolates, 746 screen-positive isolates (11.6%) were referred to a research facility and investigated to determine the prevalence of ESBLs in all gram-negative isolates, tran

SUBMITTER: Moland ES 

PROVIDER: S-EPMC1594717 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature