Growth phase- and nutrient limitation-associated transcript abundance regulation in Bordetella pertussis.

ABSTRACT: To survive in a host environment, microbial pathogens must sense local conditions, including nutrient availability, and adjust their growth state and virulence functions accordingly. No comprehensive investigation of growth phase-related gene regulation in Bordetella pertussis has been reported previously. We characterized changes in genome-wide transcript abundance of B. pertussis as a function of growth phase and availability of glutamate, a key nutrient for this organism. Using a Bordetella DNA microarray, we discovered significant changes in transcript abundance for 861 array elements during the transition from log phase to stationary phase, including declining transcript levels of many virulence factor genes. The responses to glutamate depletion exhibited similarities to the responses

SUBMITTER: Nakamura MM 

PROVIDER: S-EPMC1594893 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature