Characterization and prediction of protein-protein interactions within and between complexes.

ABSTRACT: Databases of experimentally determined protein interactions provide information on binary interactions and on involvement in multiprotein complexes. These data are valuable for understanding the general properties of the interaction between proteins as well as for the development of prediction schemes for unknown interactions. Here we analyze experimentally determined protein interactions by measuring various sequence, genomic, transcriptomic, and proteomic attributes of each interacting pair in the yeast Saccharomyces cerevisiae. We find that dividing the data into two groups, one that includes binary interactions within protein complexes (stable) and another that includes binary interactions that are not within complexes (transient), enables better characterization of the interactions by

SUBMITTER: Sprinzak E 

PROVIDER: S-EPMC1595418 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature