Characterization of neutralizing epitopes within the major capsid protein of human papillomavirus type 33.

ABSTRACT:

Background

Infections with papillomaviruses induce type-specific immune responses, mainly directed against the major capsid protein, L1. Based on the propensity of the L1 protein to self-assemble into virus-like particles (VLPs), type-specific vaccines have already been developed. In order to generate vaccines that target a broader spectrum of HPV types, extended knowledge of neutralizing epitopes is required. Despite the association of human papillomavirus type 33 (HPV33) with cervical carcinomas, fine mapping of neutralizing conformational epitopes on HPV33 has not been reported yet. By loop swapping between HPV33 and HPV16 capsid proteins, we have identified amino acid sequences critical for the binding of conformation-dependent type-specific neutralizing antibodies to surface-e

SUBMITTER: Roth SD 

PROVIDER: S-EPMC1599721 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature