Cross-protective immunity can account for the alternating epidemic pattern of dengue virus serotypes circulating in Bangkok.

ABSTRACT: Dengue virus, the causative agent of dengue fever and its more serious manifestation dengue hemorrhagic fever, is widespread throughout tropical and subtropical regions. The virus exists as four distinct serotypes, all of which have cocirculated in Bangkok for several decades with epidemic outbreaks occurring every 8-10 years. We analyze time-series data of monthly infection incidence, revealing a distinctive pattern with epidemics of serotypes 1, 2, and 3 occurring at approximately the same time and an isolated epidemic of serotype 4 occurring in the intervening years. Phylogenetic analysis of virus samples collected over the same period shows that clade replacement events are linked to the epidemic cycle and indicates that there is an interserotypic immune reaction. Using an epidemic mod

SUBMITTER: Adams B 

PROVIDER: S-EPMC1599940 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature