Expression of platelet derived growth factor family members and the potential role of imatinib mesylate for cervical cancer.

ABSTRACT:

Background

Despite significant achievements in the treatment of cervical cancer, it is still a deadly disease; hence newer therapeutical modalities are needed. Preliminary investigations suggest that platelet-derived growth factor (PDGF) might have a role in the development of cervical cancer, therefore it is important to determine whether this growth factor pathway is functional and its targeting with imatinib mesylate leads to growth inhibition of cervical cancer cells.

Results

PDGF receptors (PDGFR) and their ligands are frequently expressed in cervical cancer and the majority exhibited a combination of family members co-expression. A number of intronic and exonic variations but no known mutations in the coding sequence of the PDGFRalpha gene were found in cancer cell lin

SUBMITTER: Taja-Chayeb L 

PROVIDER: S-EPMC1601967 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature