Progression in cutaneous malignant melanoma is associated with distinct expression profiles: a tissue microarray-based study.

ABSTRACT: Cutaneous malignant melanoma remains the leading cause of skin cancer death in industrialized countries. Clinical and histological variables that predict survival, such as Breslow's index, tumor size, ulceration, or vascular invasion have been identified in malignant melanoma. Nevertheless, the potential relevance of biological variables still awaits an in-depth exploration. Using tissue microarrays (TMAs), we retrospectively analyzed 165 malignant melanoma samples from 88 patients corresponding to distinct histological progression phases, radial, vertical, and metastases. A panel of 39 different antibodies for cell cycle, apoptosis, melanoma antigens, transcription factors, DNA mismatch repair, and other proteins was used. Integrating the information, the study has identified expression p

SUBMITTER: Alonso SR 

PROVIDER: S-EPMC1602212 | biostudies-literature | 2004 Jan

REPOSITORIES: biostudies-literature