Intracellular demography and the dynamics of Salmonella enterica infections.

ABSTRACT: An understanding of within-host dynamics of pathogen interactions with eukaryotic cells can shape the development of effective preventive measures and drug regimes. Such investigations have been hampered by the difficulty of identifying and observing directly, within live tissues, the multiple key variables that underlay infection processes. Fluorescence microscopy data on intracellular distributions of Salmonella enterica serovar Typhimurium (S. Typhimurium) show that, while the number of infected cells increases with time, the distribution of bacteria between cells is stationary (though highly skewed). Here, we report a simple model framework for the intensity of intracellular infection that links the quasi-stationary distribution of bacteria to bacterial and cellular demography. This en

SUBMITTER: Brown SP 

PROVIDER: S-EPMC1609125 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature