Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model.

ABSTRACT: Human adenocarcinoma (AC) is the most frequently diagnosed human lung cancer, and its absolute incidence is increasing dramatically. Compared to human lung AC, the A/J mouse-urethane model exhibits similar histological appearance and molecular changes. We examined the gene expression profiles of human and murine lung tissues (normal or AC) and compared the two species' datasets after aligning approximately 7500 orthologous genes. A list of 409 gene classifiers (P value <0.0001), common to both species (joint classifiers), showed significant, positive correlation in expression levels between the two species. A number of previously reported expression changes were recapitulated in both species, such as changes in glycolytic enzymes and cell-cycle proteins. Unexpectedly, joint classifiers in

SUBMITTER: Stearman RS 

PROVIDER: S-EPMC1613183 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature