Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis.

ABSTRACT: Asthma is on the rise despite intense, ongoing research underscoring the need for new scientific inquiry. In an effort to provide unbiased insight into disease pathogenesis, we took an approach involving expression profiling of lung tissue from mice with experimental asthma. Employing asthma models induced by different allergens and protocols, we identified 6.5% of the tested genome whose expression was altered in an asthmatic lung. Notably, two phenotypically similar models of experimental asthma were shown to have distinct transcript profiles. Genes related to metabolism of basic amino acids, specifically the cationic amino acid transporter 2, arginase I, and arginase II, were particularly prominent among the asthma signature genes. In situ hybridization demonstrated marked staining of a

SUBMITTER: Zimmermann N 

PROVIDER: S-EPMC161427 | biostudies-literature | 2003 Jun

REPOSITORIES: biostudies-literature