Effectiveness of neuraminidase inhibitors in treatment and prevention of influenza A and B: systematic review and meta-analyses of randomised controlled trials.

ABSTRACT:

Objective

To review the clinical effectiveness of oseltamivir and zanamivir for the treatment and prevention of influenza A and B.

Design

Systematic review and meta-analyses of randomised controlled trials.

Data sources

Published studies were retrieved from electronic bibliographic databases; supplementary data were obtained from the manufacturers.

Selection of studies

Randomised controlled, double blind trials that were published in English, had data available before 31 December 2001, evaluated treatment or prevention of naturally occurring influenza with zanamivir or oseltamivir (if given using the formulation and dosage licensed for clinical use), and reported at least one end point of relevance.

Review methods

The main outcome measures were the media

SUBMITTER: Cooper NJ 

PROVIDER: S-EPMC161558 | biostudies-literature | 2003 Jun

REPOSITORIES: biostudies-literature