A missense mutation in PMEL17 is associated with the Silver coat color in the horse.

ABSTRACT:

Background

The Silver coat color, also called Silver dapple, in the horse is characterized by dilution of the black pigment in the hair. This phenotype shows an autosomal dominant inheritance. The effect of the mutation is most visible in the long hairs of the mane and tail, which are diluted to a mixture of white and gray hairs. Herein we describe the identification of the responsible gene and a missense mutation associated with the Silver phenotype.

Results

Segregation data on the Silver locus (Z) were obtained within one half-sib family that consisted of a heterozygous Silver colored stallion with 34 offspring and their 29 non-Silver dams. We typed 41 genetic markers well spread over the horse genome, including one single microsatellite marker (TKY284) close to the candid

SUBMITTER: Brunberg E 

PROVIDER: S-EPMC1617113 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature