A phase 2b randomised trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in Kenya.

ABSTRACT:

Objective

The objective was to measure the efficacy of the vaccination regimen FFM ME-TRAP in preventing episodes of clinical malaria among children in a malaria endemic area. FFM ME-TRAP is sequential immunisation with two attenuated poxvirus vectors (FP9 and modified vaccinia virus Ankara), which both deliver the pre-erythrocytic malaria antigen construct multiple epitope-thrombospondin-related adhesion protein (ME-TRAP).

Design

The trial was randomised and double-blinded.

Setting

The setting was a rural, malaria-endemic area of coastal Kenya.

Participants

We vaccinated 405 healthy 1- to 6-year-old children.

Interventions

Participants were randomised to vaccination with either FFM ME-TRAP or control (rabies vaccine).

Outcome measures

Following a

SUBMITTER: Bejon P 

PROVIDER: S-EPMC1617125 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature