Assessing systems properties of yeast mitochondria through an interaction map of the organelle.

ABSTRACT: Mitochondria carry out specialized functions; compartmentalized, yet integrated into the metabolic and signaling processes of the cell. Although many mitochondrial proteins have been identified, understanding their functional interrelationships has been a challenge. Here we construct a comprehensive network of the mitochondrial system. We integrated genome-wide datasets to generate an accurate and inclusive mitochondrial parts list. Together with benchmarked measures of protein interactions, a network of mitochondria was constructed in their cellular context, including extra-mitochondrial proteins. This network also integrates data from different organisms to expand the known mitochondrial biology beyond the information in the existing databases. Our network brings together annotated and p

SUBMITTER: Perocchi F 

PROVIDER: S-EPMC1617129 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature