The transcriptional regulator CBP has defined spatial associations within interphase nuclei.

ABSTRACT: It is becoming increasingly clear that nuclear macromolecules and macromolecular complexes are compartmentalized through binding interactions into an apparent three-dimensionally ordered structure. This ordering, however, does not appear to be deterministic to the extent that chromatin and nonchromatin structures maintain a strict 3-D arrangement. Rather, spatial ordering within the cell nucleus appears to conform to stochastic rather than deterministic spatial relationships. The stochastic nature of organization becomes particularly problematic when any attempt is made to describe the spatial relationship between proteins involved in the regulation of the genome. The CREB-binding protein (CBP) is one such transcriptional regulator that, when visualised by confocal microscopy, reveals a hi

SUBMITTER: McManus KJ 

PROVIDER: S-EPMC1617132 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature