Ontology highlight
ABSTRACT:
SUBMITTER: Shimojima M
PROVIDER: S-EPMC1617303 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Shimojima Masayuki M Takada Ayato A Ebihara Hideki H Neumann Gabriele G Fujioka Kouki K Irimura Tatsuro T Jones Steven S Feldmann Heinz H Kawaoka Yoshihiro Y
Journal of virology 20061001 20
Filoviruses, represented by the genera Ebolavirus and Marburgvirus, cause a lethal hemorrhagic fever in humans and in nonhuman primates. Although filovirus can replicate in various tissues or cell types in these animals, the molecular mechanisms of its broad tropism remain poorly understood. Here we show the involvement of members of the Tyro3 receptor tyrosine kinase family-Axl, Dtk, and Mer-in cell entry of filoviruses. Ectopic expression of these family members in lymphoid cells, which otherw ...[more]