A high resolution physical and RH map of pig chromosome 6q1.2 and comparative analysis with human chromosome 19q13.1.

ABSTRACT:

Background

The generation of BAC/PAC contigs in targeted genome regions is a powerful method to establish high-resolution physical maps. In domestic animal species the generation of such contigs is typically initiated with the screening of libraries with probes derived from human genes that are expected to be located in the region of interest by comparative mapping. However, in many instances the available gene-derived probes are too far apart to allow the cloning of BAC/PAC contigs larger than a few hundred kb. High resolution physical mapping allows to estimate the sizes of gaps and to control the orientation of the individual sub-contigs, which helps to avoid errors during the assembly of smaller contigs into final Mb-sized contigs. The recently constructed porcine IMNpRH2 panel

SUBMITTER: Martins-Wess F 

PROVIDER: S-EPMC161799 | biostudies-literature | 2003 May

REPOSITORIES: biostudies-literature