Identification of regeneration-associated genes after central and peripheral nerve injury in the adult rat.

ABSTRACT:

Background

It is well known that neurons of the peripheral nervous system have the capacity to regenerate a severed axon leading to functional recovery, whereas neurons of the central nervous system do not regenerate successfully after injury. The underlying molecular programs initiated by axotomized peripheral and central nervous system neurons are not yet fully understood.

Results

To gain insight into the molecular mechanisms underlying the process of regeneration in the nervous system, differential display polymerase chain reaction has been used to identify differentially expressed genes following axotomy of peripheral and central nerve fibers. For this purpose, axotomy induced changes of regenerating facial nucleus neurons, and non-regenerating red nucleus and Clarke's n

SUBMITTER: Schmitt AB 

PROVIDER: S-EPMC161801 | biostudies-literature | 2003 May

REPOSITORIES: biostudies-literature