Ether a go-go potassium channel expression in soft tissue sarcoma patients.

ABSTRACT:

Background

The expression of the human Eag1 potassium channel (Kv10.1) is normally restricted to the adult brain, but it has been detected in both tumour cell lines and primary tumours. Our purpose was to determine the frequency of expression of Eag1 in soft tissue sarcoma and its potential clinical implications.

Results

We used specific monoclonal antibodies to determine the expression levels of Eag1 in soft tissue sarcomas from 210 patients by immunohistochemistry. Eag1 was expressed in 71% of all tumours, with frequencies ranging from 56% (liposarcoma) to 82% (rhabdomyosarcoma). We detected differences in expression levels depending on the histological type, but no association was seen between expression of this protein and sex, age, grade or tumour size. Four cell lines

SUBMITTER: Mello de Queiroz F 

PROVIDER: S-EPMC1618397 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature