Insights into the evolution of the ErbB receptor family and their ligands from sequence analysis.

ABSTRACT:

Background

In the time since we presented the first molecular evolutionary study of the ErbB family of receptors and the EGF family of ligands, there has been a dramatic increase in genomic sequences available. We have utilized this greatly expanded data set in this study of the ErbB family of receptors and their ligands.

Results

In our previous analysis we postulated that EGF family ligands could be characterized by the presence of a splice site in the coding region between the fourth and fifth cysteines of the EGF module and the placement of that module near the transmembrane domain. The recent identification of several new ligands for the ErbB receptors supports this characterization of an ErbB ligand; further, applying this characterization to available sequences suggest

SUBMITTER: Stein RA 

PROVIDER: S-EPMC1618406 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature