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Inhibitory activities of quinolones against DNA gyrase of Chlamydia pneumoniae.

ABSTRACT: The gyrA and gyrB genes of Chlamydia pneumoniae TW-183 were cloned, and their proteins were purified by use of a fusion system with a maltose-binding protein. The 50% inhibitory concentrations of garenoxacin, sparfloxacin, moxifloxacin, gatifloxacin, and levofloxacin were 10.1, 47.5, 39.6, 64.2, and 156.9 microg/ml, respectively, and the MICs against C. pneumoniae TW-183 were 0.008, 0.016, 0.063, 0.125, and 0.25 microg/ml, respectively.

SUBMITTER: Ameyama S 

PROVIDER: S-EPMC161870 | biostudies-literature | 2003 Jul

REPOSITORIES: biostudies-literature

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Inhibitory activities of quinolones against DNA gyrase of Chlamydia pneumoniae.

Ameyama Satoshi S   Shinmura Yuko Y   Takahata Masahiro M  

Antimicrobial agents and chemotherapy 20030701 7

The gyrA and gyrB genes of Chlamydia pneumoniae TW-183 were cloned, and their proteins were purified by use of a fusion system with a maltose-binding protein. The 50% inhibitory concentrations of garenoxacin, sparfloxacin, moxifloxacin, gatifloxacin, and levofloxacin were 10.1, 47.5, 39.6, 64.2, and 156.9 microg/ml, respectively, and the MICs against C. pneumoniae TW-183 were 0.008, 0.016, 0.063, 0.125, and 0.25 microg/ml, respectively. ...[more]

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