Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires.

ABSTRACT:

Background

The peptidyl-prolyl cis/trans isomerase (PPIase) class of proteins is present in all known eukaryotes, prokaryotes, and archaea, and it is comprised of three member families that share the ability to catalyze the cis/trans isomerisation of a prolyl bond. Some fungi have been used as model systems to investigate the role of PPIases within the cell, however how representative these repertoires are of other fungi or humans has not been fully investigated.

Results

PPIase numbers within these fungal repertoires appears associated with genome size and orthology between repertoires was found to be low. Phylogenetic analysis showed the single-domain FKBPs to evolve prior to the multi-domain FKBPs, whereas the multi-domain cyclophilins appear to evolve throughout cyclophil

SUBMITTER: Pemberton TJ 

PROVIDER: S-EPMC1618848 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature