Predicting residue-wise contact orders in proteins by support vector regression.

ABSTRACT:

Background

The residue-wise contact order (RWCO) describes the sequence separations between the residues of interest and its contacting residues in a protein sequence. It is a new kind of one-dimensional protein structure that represents the extent of long-range contacts and is considered as a generalization of contact order. Together with secondary structure, accessible surface area, the B factor, and contact number, RWCO provides comprehensive and indispensable important information to reconstructing the protein three-dimensional structure from a set of one-dimensional structural properties. Accurately predicting RWCO values could have many important applications in protein three-dimensional structure prediction and protein folding rate prediction, and give deep insights into pro

SUBMITTER: Song J 

PROVIDER: S-EPMC1618864 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature