Thioredoxin from Brugia malayi: defining a 16-kilodalton class of thioredoxins from nematodes.

ABSTRACT: Thioredoxins are a family of small redox proteins that undergo NADPH-dependent reduction by thioredoxin reductase. This results in a supply of reducing equivalents that cells use in a wide variety of biological reactions, which include maintaining reduced forms of the enzymes important for protection against damage from high-energy oxygen radicals, the regulation of transcription factor activity, and the inhibition of apoptosis. Here we report on a new member of the thioredoxin family of proteins from the filarial nematode Brugia malayi, Bm-TRX-1, which defines a new subclass of 16-kDa thioredoxins that occur widely in nematodes, including Caenorhabditis elegans. In addition to being larger than the thioredoxins found in mammalian and bacterial species, the putative active site sequence of

SUBMITTER: Kunchithapautham K 

PROVIDER: S-EPMC162031 | biostudies-literature | 2003 Jul

REPOSITORIES: biostudies-literature