Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions.

ABSTRACT:

Background

Folate metabolism pathway genes have been examined for association with neural tube defects (NTDs) because folic acid supplementation reduces the risk of this debilitating birth defect. Most studies addressed these genes individually, often with different populations providing conflicting results.

Objectives

Our study evaluates several folate pathway genes for association with human NTDs, incorporating an environmental cofactor: maternal folate supplementation.

Methods

In 304 Caucasian American NTD families with myelomeningocele or anencephaly, we examined 28 polymorphisms in 11 genes: folate receptor 1, folate receptor 2, solute carrier family 19 member 1, transcobalamin II, methylenetetrahydrofolate dehydrogenase 1, serine hydroxymethyl-transferase 1, 5,1

SUBMITTER: Boyles AL 

PROVIDER: S-EPMC1626421 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature