Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer.

ABSTRACT:

Background

A better understanding of the development of metastatic disease and the identification of molecular markers for cancer spread would be useful for the design of improved treatment strategies. This study was conducted to identify gene expressions associated with metastatic phenotypes of locally advanced cervical carcinomas and investigate whether gains or losses of these genes could play a role in regulation of the transcripts. Gene expressions and copy number changes were determined in primary tumors from 29 patients with and 19 without diagnosed lymph node metastases by use of cDNA and genomic microarray techniques, respectively.

Results

Thirty-one genes that differed in expression between the node positive and negative tumors were identified. Expressions of eight

SUBMITTER: Lyng H 

PROVIDER: S-EPMC1626467 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature