The SNARE protein family of Leishmania major.

ABSTRACT:

Background

Leishmania major is a protozoan parasite with a highly polarised cell shape that depends upon endocytosis and exocytosis from a single area of the plasma membrane, the flagellar pocket. SNAREs (soluble N-ethylmaleimide-sensitive factor adaptor proteins receptors) are key components of the intracellular vesicle-mediated transports that take place in all eukaryotic cells. They are membrane-bound proteins that facilitate the docking and fusion of vesicles with organelles. The recent availability of the genome sequence of L. major has allowed us to assess the complement of SNAREs in the parasite and to investigate their location in comparison with metazoans.

Results

Bioinformatic searches of the L. major genome revealed a total of 27 SNARE domain-containing proteins t

SUBMITTER: Besteiro S 

PROVIDER: S-EPMC1626469 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature