Time to renal disease and end-stage renal disease in PROFILE: a multiethnic lupus cohort.

ABSTRACT:

Background

Renal involvement is a serious manifestation of systemic lupus erythematosus (SLE); it may portend a poor prognosis as it may lead to end-stage renal disease (ESRD). The purpose of this study was to determine the factors predicting the development of renal involvement and its progression to ESRD in a multi-ethnic SLE cohort (PROFILE).

Methods and findings

PROFILE includes SLE patients from five different United States institutions. We examined at baseline the socioeconomic-demographic, clinical, and genetic variables associated with the development of renal involvement and its progression to ESRD by univariable and multivariable Cox proportional hazards regression analyses. Analyses of onset of renal involvement included only patients with renal involvement after

SUBMITTER: Alarcon GS 

PROVIDER: S-EPMC1626549 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature