Association of MTHFR gene polymorphisms with breast cancer survival.

ABSTRACT:

Background

Two functional single nucleotide polymorphisms (SNPs) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, lead to decreased enzyme activity and affect chemosensitivity of tumor cells. We investigated whether these MTHFR SNPs were associated with breast cancer survival in African-American and Caucasian women.

Methods

African-American (n = 143) and Caucasian (n = 105) women, who had incident breast cancer with surgery, were recruited between 1993 and 2003 from the greater Baltimore area, Maryland, USA. Kaplan-Meier survival and multivariate Cox proportional hazards regression analyses were used to examine the relationship between MTHFR SNPs and disease-specific survival.

Results

We observed opposite effects of the MTHFR polymorphis

SUBMITTER: Martin DN 

PROVIDER: S-EPMC1634868 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature