Polymorphisms within inflammatory genes and colorectal cancer.

ABSTRACT:

Background

Chronic inflammation is a risk factor for colorectal cancer and polymorphisms in the inflammatory genes could modulate the levels of inflammation. We have investigated ten single nucleotide polymorphisms (SNPs) in the following inflammation-related genes: TLR4 (Asp299Gly), CD14 (-260 T>C), MCP1 (-2518 A>G), IL12A (+7506 A>T, +8707 A>G, +9177 T>A, +9508 G>A), NOS2A (+524T>C), TNF (-857C>T), and PTGS1 (V444I) in 377 colorectal (CRC) cancer cases and 326 controls from Barcelona (Spain).

Results

There was no statistically significant association between the SNPs investigated and colorectal cancer risk.

Conclusion

The lack of association may show that the inflammatory genes selected for this study are not involved in the carcinogenic process of colorectum. Alter

SUBMITTER: Landi S 

PROVIDER: S-EPMC1634873 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature