Thirteen is enough: the myosins of Dictyostelium discoideum and their light chains.

ABSTRACT:

Background

Dictyostelium discoideum is one of the most famous model organisms for studying motile processes like cell movement, organelle transport, cytokinesis, and endocytosis. Members of the myosin superfamily, that move on actin filaments and power many of these tasks, are tripartite proteins consisting of a conserved catalytic domain followed by the neck region consisting of a different number of so-called IQ motifs for binding of light chains. The tails contain functional motifs that are responsible for the accomplishment of the different tasks in the cell. Unicellular organisms like yeasts contain three to five myosins while vertebrates express over 40 different myosin genes. Recently, the question has been raised how many myosins a simple multicellular organism like Dictyos

SUBMITTER: Kollmar M 

PROVIDER: S-EPMC1634994 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature