Gene transfer in humans using a conditionally replicating lentiviral vector.
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ABSTRACT:
SUBMITTER: Levine BL
PROVIDER: S-EPMC1635018 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Publications
Gene transfer in humans using a conditionally replicating lentiviral vector.
Levine Bruce L BL Humeau Laurent M LM Boyer Jean J MacGregor Rob-Roy RR Rebello Tessio T Lu Xiaobin X Binder Gwendolyn K GK Slepushkin Vladimir V Lemiale Franck F Mascola John R JR Bushman Frederic D FD Dropulic Boro B June Carl H CH
Proceedings of the National Academy of Sciences of the United States of America 20061107 46
We report findings from a clinical evaluation of lentiviral vectors in a phase I open-label nonrandomized clinical trial for HIV. This trial evaluated the safety of a conditionally replicating HIV-1-derived vector expressing an antisense gene against the HIV envelope. Five subjects with chronic HIV infection who had failed to respond to at least two antiviral regimens were enrolled. A single i.v. infusion of gene-modified autologous CD4 T cells was well tolerated in all patients. Viral loads wer ...[more]
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