Differential regulation of the zebrafish orthopedia 1 gene during fate determination of diencephalic neurons.

ABSTRACT:

Background

The homeodomain transcription factor Orthopedia (Otp) is essential in restricting the fate of multiple classes of secreting neurons in the neuroendocrine hypothalamus of vertebrates. However, there is little information on the intercellular factors that regulate Otp expression during development.

Results

Here, we identified two otp orthologues in zebrafish (otp1 and otp2) and explored otp1 in the context of the morphogenetic pathways that specify neuroectodermal regions. During forebrain development, otp1 is expressed in anterior groups of diencephalic cells, positioned in the preoptic area (PO) (anterior alar plate) and the posterior tuberculum (PT) (posterior basal plate). The latter structure is characterized by Tyrosine Hydroxylase (TH)-positive cells, suggest

SUBMITTER: Del Giacco L 

PROVIDER: S-EPMC1635040 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature