Evidence of recombination in quasispecies populations of a Hepatitis C Virus patient undergoing anti-viral therapy.

ABSTRACT:

Background/aim

Hepatitis C virus (HCV) has been the subject of intense research and clinical investigation as its major role in human disease has emerged. HCV circulates in vivo as a complex population of different but closely related viral variants, commonly referred to as a quasispecies. The extent to which recombination plays a role in the evolution of HCV quasispecies when patients are undergoing anti-viral therapy is currently unknown. In order to gain insight into these matters, we have performed a phylogenetic analysis of HCV quasispecies populations from six patients undergoing anti-viral therapy.

Methods

Putative recombinant sequences were identified with the use of SimPlot program. Recombination events were confirmed by bootscaning, using putative recombinant seque

SUBMITTER: Moreno MP 

PROVIDER: S-EPMC1635042 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature