TOPOFIT-DB, a database of protein structural alignments based on the TOPOFIT method.

ABSTRACT: TOPOFIT-DB (T-DB) is a public web-based database of protein structural alignments based on the TOPOFIT method, providing a comprehensive resource for comparative analysis of protein structure families. The TOPOFIT method is based on the discovery of a saturation point on the alignment curve (topomax point) which presents an ability to objectively identify a border between common and variable parts in a protein structural family, providing additional insight into protein comparison and functional annotation. TOPOFIT also effectively detects non-sequential relations between protein structures. T-DB provides users with the convenient ability to retrieve and analyze structural neighbors for a protein; do one-to-all calculation of a user provided structure against the entire current PDB release

SUBMITTER: Leslin CM 

PROVIDER: S-EPMC1635338 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature