Nuclear envelope transmembrane proteins (NETs) that are up-regulated during myogenesis.

ABSTRACT:

Background

The nuclear lamina is a protein meshwork lining the inner nuclear membrane, which contains a polymer of nuclear lamins associated with transmembrane proteins of the inner nuclear membrane. The lamina is involved in nuclear structure, gene expression, and association of the cytoplasmic cytoskeleton with the nucleus. We previously identified a group of 67 novel putative nuclear envelope transmembrane proteins (NETs) in a large-scale proteomics analysis. Because mutations in lamina proteins have been linked to several human diseases affecting skeletal muscle, we examined NET expression during differentiation of C2C12 myoblasts. Our goal was to identify new nuclear envelope and lamina components whose expression is coordinated with muscle differentiation.

Results

Usin

SUBMITTER: Chen IH 

PROVIDER: S-EPMC1635557 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature